PhIP-d3
PhIP-d3 (2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-d3) is the deuterium labeled PhIP. PhIP (2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) is the most abundant of generation of heterocyclic amines (HCA), resulted in the cooking of meat[1][2]. DNA damaging and mutagenic activities. PhIP also has oestrogenic activity that could contribute to its tissue specific carcinogenicity[2].
Product Specifications
CAS Number
210049-13-1
Product Name Alternative
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-d3
UNSPSC
12352005
Target
Isotope-Labeled Compounds
Related Pathways
Others
Field of Research
Cancer
Smiles
[2H]C([2H])([2H])N1C(N)=NC2=NC=C(C=C21)C3=CC=CC=C3
Molecular Formula
C13H9D3N4
Molecular Weight
227.28
References & Citations
[1]Bellamri M, et al. Metabolic Activation of the Cooked Meat Carcinogen 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine in Human Prostate. Toxicol Sci. 2018 Jun 1;163 (2) :543-556.|[2]Papaioannou MD, et ak. The cooked meat-derived mammary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) elicits estrogenic-like microRNA responses in breast cancer cells. Toxicol Lett. 2014 Aug 17;229 (1) :9-16.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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