PhIP-d3

PhIP-d3 (2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-d3) is the deuterium labeled PhIP (HY-118716) . PhIP (2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) is the most abundant of generation of heterocyclic amines (HCA), resulted in the cooking of meat[1][2]. DNA damaging and mutagenic activities. PhIP also has oestrogenic activity that could contribute to its tissue specific carcinogenicity[2].

Product Specifications

CAS Number

[210049-13-1]

Product Name Alternative

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-d3

UNSPSC

12352005

Target

Isotope-Labeled Compounds

Related Pathways

Others

Field of Research

Cancer

Smiles

[2H]C([2H])([2H])N1C(N)=NC2=NC=C(C=C21)C3=CC=CC=C3

Molecular Formula

C13H9D3N4

Molecular Weight

227.28

References & Citations

[1]Bellamri M, et al. Metabolic Activation of the Cooked Meat Carcinogen 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine in Human Prostate. Toxicol Sci. 2018 Jun 1;163 (2) :543-556.|[2]Papaioannou MD, et ak. The cooked meat-derived mammary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) elicits estrogenic-like microRNA responses in breast cancer cells. Toxicol Lett. 2014 Aug 17;229 (1) :9-16.