HI-346
HI-346 is a non-nucleoside reverse transcriptase inhibitor (NNRTI) for HIV-1 with an IC50 value against the HIV-1 virus strain (HTLV-IIIB) of 3 nM. HI-346 is a vaginal bactericidal contraceptive agent, with its sperm-killing activity having an EC50 value of 42 μM. HI-346 shows no cytotoxicity to normal cells at effective concentrations. HI-346 can be used in anti-HIV-1 and contraceptive research[1].
Product Specifications
CAS Number
[149486-68-0]
UNSPSC
12352005
Target
HIV; Reverse Transcriptase
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
BrC1=CC=C(NC(NCCC2=CCCCC2)=S)N=C1
Molecular Formula
C14H18BrN3S
Molecular Weight
340.28
References & Citations
[1]D’Cruz OJ, Venkatachalam TK, Uckun FM. Novel thiourea compounds as dual-function microbicides. Biology of reproduction. 2000 Jul 1;63 (1) :196-205.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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