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HI-346

HI-346 is a non-nucleoside reverse transcriptase inhibitor (NNRTI) for HIV-1 with an IC50 value against the HIV-1 virus strain (HTLV-IIIB) of 3 nM. HI-346 is a vaginal bactericidal contraceptive agent, with its sperm-killing activity having an EC50 value of 42 μM. HI-346 shows no cytotoxicity to normal cells at effective concentrations. HI-346 can be used in anti-HIV-1 and contraceptive research[1].

Product Specifications

CAS Number

149486-68-0

UNSPSC

12352005

Target

HIV; Reverse Transcriptase

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Smiles

BrC1=CC=C(NC(NCCC2=CCCCC2)=S)N=C1

Molecular Formula

C14H18BrN3S

Molecular Weight

340.28

References & Citations

[1]D’Cruz OJ, Venkatachalam TK, Uckun FM. Novel thiourea compounds as dual-function microbicides. Biology of reproduction. 2000 Jul 1;63 (1) :196-205.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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