NS-6740
NS-6740 is a 7 nAChRs partial agonist with a Ki of 1.1 nM. NS-6740 is also an effective modulator of the cholinergic anti-inflammatory pathway. NS-6740 switched the signaling mode of 7 in a channel-independent manner, which reduces synaptic function. NS-6740 can induce the desensitization state of 7 nAChRs. NS-6740 can result in the generation of robust nAChR-mediated currents. NS-6740 reduces lipopolysaccharide-induced TNF-α release from microglia. NS-6740 can be studied in research on inflammatory and neurological disease such as chronic and neuropathic pain[1][2][3].
Product Specifications
CAS Number
753500-02-6
UNSPSC
12352005
Target
NAChR
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
O=C(C1=CC=C(O1)C2=CC=CC(C(F)(F)F)=C2)N3CCN4CCC3CC4
Molecular Formula
C19H19F3N2O2
Molecular Weight
364.36
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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