NS-6740

NS-6740 is a 7 nAChRs partial agonist with a Ki of 1.1 nM. NS-6740 is also an effective modulator of the cholinergic anti-inflammatory pathway. NS-6740 switched the signaling mode of 7 in a channel-independent manner, which reduces synaptic function. NS-6740 can induce the desensitization state of 7 nAChRs. NS-6740 can result in the generation of robust nAChR-mediated currents. NS-6740 reduces lipopolysaccharide-induced TNF-α release from microglia. NS-6740 can be studied in research on inflammatory and neurological disease such as chronic and neuropathic pain[1][2][3].

Product Specifications

CAS Number

[753500-02-6]

UNSPSC

12352005

Target

NAChR

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Neurological Disease

Smiles

O=C(C1=CC=C(O1)C2=CC=CC(C(F)(F)F)=C2)N3CCN4CCC3CC4

Molecular Formula

C19H19F3N2O2

Molecular Weight

364.36

References & Citations

[1]Sasaki, T., et al., (2024) . Modulation of Ca2+ oscillation following ischemia and nicotinic acetylcholine receptors in primary cortical neurons by high-throughput analysis. Scientific reports, 14 (1), 27667.|[2]Thomsen MS, et al., The α7 nicotinic acetylcholine receptor ligands methyllycaconitine, NS6740 and GTS-21 reduce lipopolysaccharide-induced TNF-α release from microglia. J Neuroimmunol. 2012 Oct 15;251 (1-2) :65-72. |[3]Papke RL, et al., NS6740, an α7 nicotinic acetylcholine receptor silent agonist, disrupts hippocampal synaptic plasticity. Neurosci Lett. 2018 Jun 11;677:6-13.