TP-110
TP-110 is a proteasome inhibitor. TP-110 specifically inhibits the protease-like activity of the 20S proteasome, but does not affect the trypsin-like or peptidyl-glutamyl peptide hydrolysis activity. TP-110 inhibits the NF-κB pathway, activates caspase-8, -9, and -3, and causes PARP cleavage, significantly reducing the levels of cIAP-1 and XIAP. TP-110 causes cell cycle arrest at the G2/M phase and promotes apoptosis of cancer cells. TP-110 can be used in cancer research of prostate cancer and multiple myeloma, etc[1][2].
Product Specifications
CAS Number
688737-95-3
UNSPSC
12352005
Target
Apoptosis; Caspase; IAP; NF-κB; PARP; Proteasome
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
CC([C@@H](C(N)=O)N(C([C@H](CC1=CC=C(C=C1)OC)NC(CC2=C3C=CC=CC3=CC=C2)=O)=O)C(CC4=CC=C(C=C4)OC)C=O)C
Molecular Formula
C37H41N3O6
Molecular Weight
623.74
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3; Caspase 8; Caspase 9; cIAP-1; NF-κB; PARP; XIAP
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Recombinant Yersinia pestis bv. Antiqua Divalent-cation tolerance protein CutA (cutA)
Recombinant Yersinia pestis bv. Antiqua Divalent-cation tolerance protein CutA (cutA)
Recombinant Yersinia pestis bv. Antiqua Divalent-cation tolerance protein CutA (cutA)