Benzolamide (Standard)

Benzolamide (Standard) is the analytical standard of Benzolamide. This product is intended for research and analytical applications. Benzolamide (CL11366) is a potent carbonic anhydrase (CA) inhibitor, with Kis of 15 nM, 9 nM, 94 nM and 78 nM for hCA I, hCA II, EcoCAγ and VchCAγ, respectively. Benzolamide also inhibits CAS3, with a Ki of 54 nM. Benzolamide can be used for the research of glaucoma and seizures[1][2][3].

Product Specifications

CAS Number

[3368-13-6]

UNSPSC

12352100

Target

Carbonic Anhydrase; Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Neurological Disease; Cancer

Smiles

O=S(C1=NN=C(S1)NS(=O)(C2=CC=CC=C2)=O)(N)=O

Molecular Formula

C8H8N4O4S3

Molecular Weight

320.37

References & Citations

[1]Prete SD, et, al. Escherichia coli γ-carbonic anhydrase: characterisation and effects of simple aromatic/heterocyclic sulphonamide inhibitors. J Enzyme Inhib Med Chem. 2020 Dec;35 (1) :1545-1554.|[2]Vullo D, et, al. Sulfonamide Inhibition Studies of the β-Class Carbonic Anhydrase CAS3 from the Filamentous Ascomycete Sordaria macrospora. Molecules. 2020 Feb 25;25 (5) :1036.|[3]Pospelov AS, et, al. Carbonic anhydrase inhibitors suppress seizures in a rat model of birth asphyxia. Epilepsia. 2021 Jun 27.