ER-67880

ER-67880 is a potent microtubule inhibitor with an IC50 of 9.5 μM. ER-67880 exhibits anti-proliferative activity against KB, Colon 38 and P338 cells with IC50s of 0.55, 0.2 and 0.76 μg/mL. ER-67880 causes G2/M phase arrest and is accompanied by abnormal DNA replication. ER-67880 exhibits a down-regulation pattern of G1 phase-related genes. ER-67880 can be used in various cancer studies, including those of nasopharyngeal carcinoma and murine adenocarcinoma[1][2].

Product Specifications

CAS Number

[247186-96-5]

UNSPSC

12352005

Target

Microtubule/Tubulin

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=S(C1=CC=C(C=C1)OC)(NC2=CC=CC3=C2NC=C3Cl)=O

Molecular Formula

C15H13ClN2O3S

Molecular Weight

336.79

References & Citations

[1]Owa T. Chemistry and Biology of a Series of Antitumor Sulfonamides Exploiting Transcriptomic and Quantitative Proteomic Analyses for Exploring Druggable Chemical Space. Journal of Synthetic Organic Chemistry, Japan. 2006 Nov 1;64 (11) :1171-9.|[2]Owa T, et al. Array-based structure and gene expression relationship study of antitumor sulfonamides including N-[2-[ (4-hydroxyphenyl) amino]-3-pyridinyl]-4-methoxybenzenesulfonamide and N- (3-chloro-7-indolyl) -1,4-benzenedisulfonamide. J Med Chem. 2002 Oct 24;45 (22) :4913-22.