ER-67880
ER-67880 is a potent microtubule inhibitor with an IC50 of 9.5 μM. ER-67880 exhibits anti-proliferative activity against KB, Colon 38 and P338 cells with IC50s of 0.55, 0.2 and 0.76 μg/mL. ER-67880 causes G2/M phase arrest and is accompanied by abnormal DNA replication. ER-67880 exhibits a down-regulation pattern of G1 phase-related genes. ER-67880 can be used in various cancer studies, including those of nasopharyngeal carcinoma and murine adenocarcinoma[1][2].
Product Specifications
CAS Number
247186-96-5
UNSPSC
12352005
Target
Microtubule/Tubulin
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=S(C1=CC=C(C=C1)OC)(NC2=CC=CC3=C2NC=C3Cl)=O
Molecular Formula
C15H13ClN2O3S
Molecular Weight
336.79
References & Citations
[1]Owa T. Chemistry and Biology of a Series of Antitumor Sulfonamides Exploiting Transcriptomic and Quantitative Proteomic Analyses for Exploring Druggable Chemical Space. Journal of Synthetic Organic Chemistry, Japan. 2006 Nov 1;64 (11) :1171-9.|[2]Owa T, et al. Array-based structure and gene expression relationship study of antitumor sulfonamides including N-[2-[ (4-hydroxyphenyl) amino]-3-pyridinyl]-4-methoxybenzenesulfonamide and N- (3-chloro-7-indolyl) -1,4-benzenedisulfonamide. J Med Chem. 2002 Oct 24;45 (22) :4913-22.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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