Sangivamycin (Standard)
Sangivamycin (Standard) is the analytical standard of Sangivamycin. This product is intended for research and analytical applications. Sangivamycin (NSC 65346), a nucleoside analog, is a potent inhibitor of protein kinase C (PKC) with an Ki of 10 μM. Sangivamycin has potent antiproliferative activity against a variety of human cancers[1][2].
Product Specifications
CAS Number
18417-89-5
Product Name Alternative
NSC 65346 (Standard) ; BA-90912 (Standard)
UNSPSC
12352005
Target
Nucleoside Antimetabolite/Analog; PKC; Reference Standards
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Others; TGF-beta/Smad
Field of Research
Cancer
Smiles
OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C3=NC=NC(N)=C3C(C(N)=O)=C2)O1
Molecular Formula
C12H15N5O5
Molecular Weight
309.28
References & Citations
[1]Loomis CR, Bell RM. Sangivamycin, a nucleoside analogue, is a potent inhibitor of protein kinase C. J Biol Chem. 1988;263 (4) :1682-1692.|[2]Lee SA, et al. The nucleoside analog sangivamycin induces apoptotic cell death in breast carcinoma MCF7/adriamycin-resistant cells via protein kinase Cdelta and JNK activation. J Biol Chem. 2007;282 (20) :15271-15283.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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