Lu AE51090
Lu AE51090 is selective muscarinic M1 receptor agonist with blood-brain barrier penetration. Lu AE51090 activates human M1 receptor with EC50 of 61 nM, while showing no significant agonism at M2-M5 receptors. Lu AE51090 exerts procognitive effects in mice. Lu AE51090 can be used for the study of Alzheimer’s disease (AD) and cognitive impairment associated with schizophrenia (CIAS) [1].
Product Specifications
CAS Number
1186229-95-7
UNSPSC
12352005
Target
MAChR
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Purity
99.51
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(NC1CCN(CCCN2C3=CC=CC=C3OCC2=O)CC1)CC4=CC=CC=C4
Molecular Formula
C24H29N3O3
Molecular Weight
407.51
References & Citations
[1]Sams AG, et al. Discovery of N-{1-[3- (3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl) propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090) : an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential. J Med Chem. 2010 Sep 9;53 (17) :6386-97.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAChR1; mAChR2; mAChR3; mAChR4; mAChR5
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