Lu AE51090

Lu AE51090 is selective muscarinic M1 receptor agonist with blood-brain barrier penetration. Lu AE51090 activates human M1 receptor with EC50 of 61 nM, while showing no significant agonism at M2-M5 receptors. Lu AE51090 exerts procognitive effects in mice. Lu AE51090 can be used for the study of Alzheimer’s disease (AD) and cognitive impairment associated with schizophrenia (CIAS) [1].

Product Specifications

CAS Number

[1186229-95-7]

UNSPSC

12352005

Target

MAChR

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Purity

99.51

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(NC1CCN(CCCN2C3=CC=CC=C3OCC2=O)CC1)CC4=CC=CC=C4

Molecular Formula

C24H29N3O3

Molecular Weight

407.51

References & Citations

[1]Sams AG, et al. Discovery of N-{1-[3- (3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl) propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090) : an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential. J Med Chem. 2010 Sep 9;53 (17) :6386-97.