IPS-05002
IPS-05002 is an α5β1 antagonist. IPS-05002 can inhibit VEGF-stimulated human umbilical vein endothelial cell (HUVEC) proliferation, adhesion, and migration, and also suppresses tubular network formation. IPS-05002 can upregulate IKB-β, XRCC4, and downregulate Cdc6 in VEGF-induced HUVECs. IPS-05002 can be used for the study of tumor angiogenesis[1].
Product Specifications
CAS Number
1185036-77-4
UNSPSC
12352005
Target
Integrin
Related Pathways
Cytoskeleton
Field of Research
Cancer; Inflammation/Immunology
Smiles
OC1=C(C2NCCC3=C2NC4=CC=CC=C43)C(N(C(N1)=S)CC5=CC=C(C=C5)F)=O
Molecular Formula
C22H19FN4O2S
Molecular Weight
422.48
References & Citations
[1]Kim, et al. Anti-angiogenic mechanism of IPS-05002, a novel antagonist against integrin a5β1, determined by ProteoChip-based antibody array. BioChip Journal, 10 (3), 174–181.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α5β1
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC740043-500 1x 500 µL
P21 / WAF1 (WA-1), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC400026-500 1x 500 µL
ACTH (Adrenocorticotrophic Hormone) (AH26), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC401429-100 1x 100 µL
E-Cadherin / CD324 (Intercellular Junction Marker) (4A2), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC042844-500 1x 500 µL
Spastin (Sp 3G11-1), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details