GSK 1997132B
GSK 1997132B is a benzimidazole-based PPARγ partial agonist that can cross the blood-brain barrier with a pEC50 value of 8.0. GSK 1997132B has no significant effect on PPARα/δ. GSK 1997132B improves the problem of high blood clearance rate of earlier compounds, avoiding side effects such as weight gain and edema. GSK 1997132B can be used for research on Alzheimer's disease[1].
Product Specifications
CAS Number
[1168138-37-1]
UNSPSC
12352005
Target
PPAR
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Neurological Disease
Smiles
O=C(N[C@H](CC)C1=CC=CC=C1)C2=CC=C3N(C(C)=NC3=C2)CC4=NC=C(C=C4F)F
Molecular Formula
C24H22F2N4O
Molecular Weight
420.45
References & Citations
[1]Sime M, et al. Discovery of GSK1997132B a novel centrally penetrant benzimidazole PPARγ partial agonist. Bioorg Med Chem Lett. 2011 Sep 15;21 (18) :5568-72. doi: 10.1016/j.bmcl.2011.06.088. Epub 2011 Jun 29. Erratum in: Bioorg Med Chem Lett. 2013 Feb 15;23 (4) :1143. Wilson, Timothy M [corrected to Willson, Timothy M].
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PPARγ
Curated Selection
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