BRL-41992
BRL-41992 is a selective α₂B-adrenergic receptor antagonist. BRL-41992 exhibits 94-fold higher selectivity for the α₂B-receptor than for the α₂A-receptor with Kᵢ values in neonatal rat lung tissue (expressing the α₂B-receptor) and in human platelet membranes (expressing the α₂A-receptor) of 1.1 and 103.3 nM. BRL-41992 can be used to verify the functional differences of α₂ receptor subtypes[1][2].
Product Specifications
CAS Number
124097-52-5
UNSPSC
12352005
Target
Adrenergic Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
CN(CN1[C@]2(C3=CC=CC=C3CC4=CC=CC=C41)[H])[C@@H]2C
Molecular Formula
C18H20N2
Molecular Weight
264.36
References & Citations
[1]Millan MJ. Evidence that an alpha 2A-adrenoceptor subtype mediates antinociception in mice. Eur J Pharmacol. 1992 May 14;215 (2-3) :355-6. |[2]Young P, et al. Novel α2-adrenoceptor antagonists show selectivity for α2A-and α2B-adrenoceptor subtypes. European journal of pharmacology. 1989 Sep 22;168 (3) :381-6
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α adrenergic receptor
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