BIM-46068

BIM-46068 is a potent, selectively human brain Farnesyltransferase (FTase) inhibitor (IC50 = 91.4 nM) . BIM-46068 can specifically inhibit Ras processing in MiaPaCa-2 cancer cells. BIM-46068 can be used for the study of pancreatic cancer[1].

Product Specifications

CAS Number

[201487-53-8]

UNSPSC

12352005

Target

Farnesyl Transferase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

CSCC[C@@H](C(OC)=O)NC([C@H]1N(C[C@@H](NC[C@@H](N)CS)[C@@H](C)CC)CSC1(C)C)=O

Molecular Formula

C21H42N4O3S3

Molecular Weight

494.78

References & Citations

[1]Prevost GP, et al. Inhibition of human tumor cell growth in vitro and in vivo by a specific inhibitor of human farnesyltransferase: BIM-46068. Int J Cancer. 1999 Oct 8;83 (2) :283-7.