AVE-8063
AVE-8063 (AC-7739 free base) is an aminocombretastatin. AVE-8063 shows potent antitubulin activity and cytotoxicity. AVE-8063 can be used in the research of leukemia and breast cancer[1][2].
Product Specifications
CAS Number
[162705-07-9]
Product Name Alternative
AC-7739 (free base)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Microtubule/Tubulin
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.70
Smiles
O(C)C1=C(OC)C=C(/C=C\C2=CC(N)=C(OC)C=C2)C=C1OC
Molecular Formula
C18H21NO4
Molecular Weight
315.37
Precautions
H302, H315, H319, H335
References & Citations
[1]Kamal A, et al. Synthesis and biological evaluation of 1,2,3-triazole linked aminocombretastatin conjugates as mitochondrial mediated apoptosis inducers. Bioorg Med Chem. 2014 Oct 1;22 (19) :5155-67. |[2]Lee J, et al. Discovery of a potent tubulin polymerization inhibitor: synthesis and evaluation of water-soluble prodrugs of benzophenone analog. Bioorg Med Chem Lett. 2010 Nov 1;20 (21) :6327-30.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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