BMS-187308

BMS-187308 is an orally active endothelin-A (ETA) antagonist, with Kis of 4.7 nM for ETA and 1.7 μM for ETB. BMS-187308 inhibits the pressor response to ET-1 (ED25: 1.2 µmol/kg; iv) . BMS-187308 is a suitable tool for investigating the role of endothelin[1].

Product Specifications

CAS Number

[153624-15-8]

UNSPSC

12352005

Target

Endothelin Receptor

Related Pathways

GPCR/G Protein

Field of Research

Cardiovascular Disease

Smiles

O=S(C1=CC=CC=C1C2=CC=C(CC(C)C)C=C2N)(NC3=C(C)C(C)=NO3)=O

Molecular Formula

C21H25N3O3S

Molecular Weight

399.51

References & Citations

[1]Murugesan N, et al. Biphenylsulfonamide endothelin antagonists: structure-activity relationships of a series of mono- and disubstituted analogues and pharmacology of the orally active endothelin antagonist 2'-amino-N- (3,4-dimethyl-5-isoxazolyl) -4'- (2-methylpropyl) [1, 1'-biphenyl]-2-sulfonamide (BMS-187308) . J Med Chem. 1998 Dec 17;41 (26) :5198-218.