SHIN1
SHIN1 (RZ-2994) is a human serine hydroxymethyltransferse 1 and 2 (SHMT1/2) inhibitor with IC50s of 5 and 13 nM, respectively, in an in vitro assay.
Product Specifications
CAS Number
2146095-85-2
Product Name Alternative
RZ-2994
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
SHMT
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SHIN1.html
Purity
99.11
Solubility
DMSO : 66.67 mg/mL (ultrasonic)
Smiles
OCC1=CC(C2=CC=CC=C2)=CC(C3(C(C(C)=NN4)=C4OC(N)=C3C#N)C(C)C)=C1
Molecular Formula
C24H24N4O2
Molecular Weight
400.47
Precautions
H302, H315, H319
References & Citations
[1]Ducker GS, et al. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017 Oct 24;114 (43) :11404-11409.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC680149-100 1x 100 µL
CD106 / VCAM1 (1.4C3), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC040806-100 1x 100 µL
TYRP1 (Tyrosinase Related Protein 1) (TA99), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC940218-100 1x 100 µL
CD100 (Semaphorin-4D) (A8), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC550525-100 1x 100 µL
CD63 (MX-49.129.5), CF555 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC941491-100 1x 100 µL
PAX8 (Renal Cell Marker) (PAX8/1491), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC040493-500 1x 500 µL
Moesin (MSN/493), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details