SHIN1
SHIN1 (RZ-2994) is a human serine hydroxymethyltransferse 1 and 2 (SHMT1/2) inhibitor with IC50s of 5 and 13 nM, respectively, in an in vitro assay.
Product Specifications
CAS Number
[2146095-85-2]
Product Name Alternative
RZ-2994
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
SHMT
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SHIN1.html
Purity
99.11
Solubility
DMSO : 66.67 mg/mL (ultrasonic)
Smiles
OCC1=CC(C2=CC=CC=C2)=CC(C3(C(C(C)=NN4)=C4OC(N)=C3C#N)C(C)C)=C1
Molecular Formula
C24H24N4O2
Molecular Weight
400.47
Precautions
H302, H315, H319
References & Citations
[1]Ducker GS, et al. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017 Oct 24;114 (43) :11404-11409.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
bs-5317R-BF555 100 µL
Phospho-EGFR (Tyr1197) Polyclonal Antibody, AbBy Fluor™ 555 Conjugated
Ask
View Details 