Keto-itraconazole
Keto-itraconazole (keto-ITZ) is a metabolism of Itraconazole with a potent inhibitor activity of CYP3A. Keto-itraconazole shows unbound IC50 value of 4.6 nM when coincubated with human liver microsomes and midazolam[1].
Product Specifications
CAS Number
112560-33-5
Product Name Alternative
Keto-ITZ
UNSPSC
12352005
Target
Cytochrome P450
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer; Infection
Purity
98.4
Smiles
O=C1N(N=CN1C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OC[C@@H]5O[C@](CN6N=CN=C6)(OC5)C7=CC=C(C=C7Cl)Cl)C(C)C(C)=O
Molecular Formula
C35H36Cl2N8O5
Molecular Weight
719.62
References & Citations
[1]Nina Isoherranen, et al. Role of itraconazole metabolites in CYP3A4 inhibition. Drug Metab Dispos. 2004 Oct;32 (10) :1121-31.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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