Deacetoxyvinzolidine
Deacetoxyvinzolidine (KAR-2) is a bis-indol derivative with high anti-microtubular and anti-tumour activities. Deacetoxyvinzolidine exhibits high affinity for bovine purified brain tubulin (Kd of 3 μM) and inhibits microtubule assembly at a concentration of 10 nM. Deacetoxyvinzolidine does not possess anti-calmodulin activity. Deacetoxyvinzolidine can be used for the study of leukaemia[1][2].
Product Specifications
CAS Number
165659-77-8
Product Name Alternative
KAR-2
UNSPSC
12352005
Target
Microtubule/Tubulin
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Smiles
CN1[C@]2([H])[C@]3(C4=CC([C@@]5(C6=C(CC[N@@]7C[C@](C[C@](O)(C7)CC)([H])C5)C8=CC=CC=C8N6)C(OC)=O)=C(OC)C=C41)[C@]9([H])[C@](C[C@]2%10C(N(C(O%10)=O)CCCl)=O)(C=CCN9CC3)CC
Molecular Formula
C46H56ClN5O7
Molecular Weight
826.42
References & Citations
[1]Orosz F, et al. The interaction of a new anti-tumour drug, KAR-2 with calmodulin. Br J Pharmacol. 1997 Jul;121 (5) :955-62. |[2]Orosz F, et al. Interaction of a new bis-indol derivative, KAR-2 with tubulin and its antimitotic activity. Br J Pharmacol. 1997 Jul;121 (5) :947-54.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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