Deacetoxyvinzolidine

Deacetoxyvinzolidine (KAR-2) is a bis-indol derivative with high anti-microtubular and anti-tumour activities. Deacetoxyvinzolidine exhibits high affinity for bovine purified brain tubulin (Kd of 3 μM) and inhibits microtubule assembly at a concentration of 10 nM. Deacetoxyvinzolidine does not possess anti-calmodulin activity. Deacetoxyvinzolidine can be used for the study of leukaemia[1][2].

Product Specifications

CAS Number

[165659-77-8]

Product Name Alternative

KAR-2

UNSPSC

12352005

Target

Microtubule/Tubulin

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Field of Research

Cancer

Smiles

CN1[C@]2([H])[C@]3(C4=CC([C@@]5(C6=C(CC[N@@]7C[C@](C[C@](O)(C7)CC)([H])C5)C8=CC=CC=C8N6)C(OC)=O)=C(OC)C=C41)[C@]9([H])[C@](C[C@]2%10C(N(C(O%10)=O)CCCl)=O)(C=CCN9CC3)CC

Molecular Formula

C46H56ClN5O7

Molecular Weight

826.42

References & Citations

[1]Orosz F, et al. The interaction of a new anti-tumour drug, KAR-2 with calmodulin. Br J Pharmacol. 1997 Jul;121 (5) :955-62. |[2]Orosz F, et al. Interaction of a new bis-indol derivative, KAR-2 with tubulin and its antimitotic activity. Br J Pharmacol. 1997 Jul;121 (5) :947-54.