DS-1040

DS-1040 is a low-molecular-weight imidazole derivative. DS-1040 is an inhibitor of the activated thrombin-activatable fibrinolysis (TAFIa) . DS-1040 can promote fibrinolysis through suppressing TAFIa activity. DS-1040 can be studied in thrombolytic disease research[1][2].

Product Specifications

CAS Number

[1335138-62-9]

UNSPSC

12352005

Target

Thrombin

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Smiles

C[C@H]1CC[C@H](N2C=NC(C[C@@H](C(O)=O)CCCN)=C2)CC1

Molecular Formula

C16H27N3O2

Molecular Weight

293.40

References & Citations

[1]Zhou, J., et al., (2017) . A first-in-human study of DS-1040, an inhibitor of the activated form of thrombin-activatable fibrinolysis inhibitor, in healthy subjects. Journal of thrombosis and haemostasis : JTH, 15 (5), 961-971. |[2]Zhou, J., et al., (2019) . First-in-Human Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of an Oral Formulation of DS-1040, an Inhibitor of the Activated Form of Thrombin-Activatable Fibrinolysis Inhibitor, in Healthy Subjects. Journal of clinical pharmacology, 59 (12), 1669-1677.