RN983

RN983 (Compound 1) is a highly selective Bruton's tyrosine kinase (Btk) inhibitor. RN983 inhibits IgG production in B-cells with an IC50 of 2.5 nM and PGD2 production from mast cells with an IC50 of 8.3 nM. RN983 is promising for research of asthma and other allergic diseases[1].

Product Specifications

CAS Number

1423129-83-2

UNSPSC

12352005

Target

Btk

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Inflammation/Immunology

Smiles

O=C1C(NC2=NC=C(C3CCN(CC3)C)C=C2)=CC(C4=C(CO)C(N5N=CC6=C(C5=O)C(F)=CC(C(C)(C)C)=C6)=NC=C4)=NN1C

Molecular Formula

C34H37FN8O3

Molecular Weight

624.71

References & Citations

[1]Phillips JE, et al. Btk Inhibitor RN983 Delivered by Dry Powder Nose-only Aerosol Inhalation Inhibits Bronchoconstriction and Pulmonary Inflammation in the Ovalbumin Allergic Mouse Model of Asthma. J Aerosol Med Pulm Drug Deliv. 2016 Jun;29 (3) :233-41.|[2]Raman Mahadevan Iyer, et al. Inhibitors of bruton's tyrosine kinase. WO2014083026A1. 2014-06-05.