A-74932 (hydrochloride)

A-74932 hydrochloride is a potent Top II inhibitor with antitumor activity. A-74932 hydrochloride inhibits the catalytic activity of mammalian DNA topoisomerase II. A-74932 hydrochloride can be used for cancer research[1][2].

Product Specifications

CAS Number

[148201-60-9]

UNSPSC

12352005

Target

Topoisomerase

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

O=C(C1=CN2C3=C(C(N4C(NC(C(N)CCC)=O)CCC4)=C(F)C=C3C1=O)OC5=CC=CC=C25)O.Cl

Molecular Formula

C25H26ClFN4O5

Molecular Weight

516.95

References & Citations

[1]Snyder RD. Use of catalytic topoisomerase II inhibitors to probe mechanisms of chemical-induced clastogenicity in Chinese hamster V79 cells. Environ Mol Mutagen. 2000;35 (1) :13-21.|[2]Permana PA, et al. Quinobenoxazines: a class of novel antitumor quinolones and potent mammalian DNA topoisomerase II catalytic inhibitors. Biochemistry. 1994 Sep 20;33 (37) :11333-9.