A-74932 (hydrochloride)
A-74932 hydrochloride is a potent Top II inhibitor with antitumor activity. A-74932 hydrochloride inhibits the catalytic activity of mammalian DNA topoisomerase II. A-74932 hydrochloride can be used for cancer research[1][2].
Product Specifications
CAS Number
148201-60-9
UNSPSC
12352005
Target
Topoisomerase
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=C(C1=CN2C3=C(C(N4C(NC(C(N)CCC)=O)CCC4)=C(F)C=C3C1=O)OC5=CC=CC=C25)O.Cl
Molecular Formula
C25H26ClFN4O5
Molecular Weight
516.95
References & Citations
[1]Snyder RD. Use of catalytic topoisomerase II inhibitors to probe mechanisms of chemical-induced clastogenicity in Chinese hamster V79 cells. Environ Mol Mutagen. 2000;35 (1) :13-21.|[2]Permana PA, et al. Quinobenoxazines: a class of novel antitumor quinolones and potent mammalian DNA topoisomerase II catalytic inhibitors. Biochemistry. 1994 Sep 20;33 (37) :11333-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo II
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