PWZ-029

PWZ-029 is a selective inverse agonist for 5 GABAA receptors. PWZ-029 is a benzodiazepine site ligand. PWZ-029 shows a weak but significant partial agonistic effect at 1- and 3-containing receptors. PWZ-029 significantly increases retention session latency in mouse fibroblast cells. PWZ-029 can improve object recognition in normal and scopolamine-treated rat model[1][2].

Product Specifications

CAS Number

[164025-33-6]

UNSPSC

12352005

Target

GABA Receptor

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

O=C1N(CC2=C(N=CN2C3=CC=C(C=C13)Cl)COC)C

Molecular Formula

C14H14ClN3O2

Molecular Weight

291.73

References & Citations

[1]Milić, M., et al., (2013) . PWZ-029, an inverse agonist selective for α₅ GABAA receptors, improves object recognition, but not water-maze memory in normal and scopolamine-treated rats. Behavioural brain research, 241, 206-213. |[2]Savić, M. M., et al., (2008) . PWZ-029, a compound with moderate inverse agonist functional selectivity at GABA (A) receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in rats. Brain research, 1208, 150-159.