LE-540

LE-540 is a RARβ-selective retinoic acid receptor antagonist (Ki=0.22 μM) . LE-540 is promising for research of cancers (particularly breast and lung cancer) [1].

Product Specifications

CAS Number

[188645-44-5]

UNSPSC

12352005

Target

RAR/RXR

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Field of Research

Cancer

Smiles

O=C(O)C1=CC=C(C2=NC3=CC4=C(C(C)(C)CCC4(C)C)C=C3N(C)C5=C6C=CC=CC6=CC=C52)C=C1

Molecular Formula

C33H32N2O2

Molecular Weight

488.62

References & Citations

[1]Li Y, et al. Identification of a novel class of retinoic acid receptor beta-selective retinoid antagonists and their inhibitory effects on AP-1 activity and retinoic acid-induced apoptosis in human breast cancer cells. J Biol Chem. 1999 May 28;274 (22) :15360-6.