LE-540
LE-540 is a RARβ-selective retinoic acid receptor antagonist (Ki=0.22 μM) . LE-540 is promising for research of cancers (particularly breast and lung cancer) [1].
Product Specifications
CAS Number
188645-44-5
UNSPSC
12352005
Target
RAR/RXR
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
O=C(O)C1=CC=C(C2=NC3=CC4=C(C(C)(C)CCC4(C)C)C=C3N(C)C5=C6C=CC=CC6=CC=C52)C=C1
Molecular Formula
C33H32N2O2
Molecular Weight
488.62
References & Citations
[1]Li Y, et al. Identification of a novel class of retinoic acid receptor beta-selective retinoid antagonists and their inhibitory effects on AP-1 activity and retinoic acid-induced apoptosis in human breast cancer cells. J Biol Chem. 1999 May 28;274 (22) :15360-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RXRβ
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TRV-0003647-01 20 µL
Polyclonal Antibody to Kruppel Like Factor 2, Lung (KLF2)
Sign In for Pricing
View Details TRV-0003647-02 100 µL
Polyclonal Antibody to Kruppel Like Factor 2, Lung (KLF2)
Sign In for Pricing
View Details TRV-0003647-03 200 µL
Polyclonal Antibody to Kruppel Like Factor 2, Lung (KLF2)
Sign In for Pricing
View Details TRV-0003647-04 1 mL
Polyclonal Antibody to Kruppel Like Factor 2, Lung (KLF2)
Sign In for Pricing
View Details 
MBS9340317-01 48 Well
Human Zinc finger MYND domain-containing protein 17, ZMYND17 ELISA Kit
Sign In for Pricing
View Details MBS9340317-02 96 Well
Human Zinc finger MYND domain-containing protein 17, ZMYND17 ELISA Kit
Sign In for Pricing
View Details