XR 5118 (hydrochloride)

XR 5118 hydrochloride is an inhibitor of plasminogen activator inhibitor 1 (PAI-1) (IC50: 12 µM) . XR5118 binds to PAI-1 and reduces plasma PAI-1 activity levels. XR5118 hydrochloride promotes endogenous thrombolysis and inhibits thrombus accretion. XR 5118 hydrochloride can be used for research of cancer and thrombotic disease[1][2].

Product Specifications

CAS Number

[174766-49-5]

UNSPSC

12352005

Target

PAI-1

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer; Cardiovascular Disease

Smiles

O=C(/C(NC/1=O)=C/C2=CC=C(SCCN(C)C)S2)NC1=C/C3=CC=CC=C3.Cl

Molecular Formula

C20H22ClN3O2S2

Molecular Weight

435.99

References & Citations

[1]Friederich PW, et al. Novel low-molecular-weight inhibitor of PAI-1 (XR5118) promotes endogenous fibrinolysis and reduces postthrombolysis thrombus growth in rabbits. Circulation. 1997 Aug 5;96 (3) :916-21.|[2]Einholm AP, et al. Biochemical mechanism of action of a diketopiperazine inactivator of plasminogen activator inhibitor-1. Biochem J. 2003 Aug 1;373 (Pt 3) :723-32.