HJC0123
HJC0123 is a STAT3 inhibitor. HJC0123 inhibits the proliferation of hepatic stellate cells and induces cell cycle arrest and apoptosis. HJC0123 reduces the phosphorylation, nuclear translocation and transcriptional activities of STAT3, increases the production of IL-6, inhibits the phosphorylation of Smad2/3 and down-regulates SOCS3. HJC0123 can be used in the study of liver fibrosis[1].
Product Specifications
CAS Number
1430420-02-2
UNSPSC
12352005
Target
Apoptosis; Interleukin Related; STAT; TGF-beta/Smad
Related Pathways
Apoptosis; Immunology/Inflammation; JAK/STAT Signaling; Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Others
Smiles
O=C(NC1=CC=C(C2=C1)C=CS2(=O)=O)C3=CC(C4=CC=CC=C4)=NC5=CC=CC=C35
Molecular Formula
C24H16N2O3S
Molecular Weight
412.46
References & Citations
[1]Nunez Lopez O, et al. STAT3 Inhibition Suppresses Hepatic Stellate Cell Fibrogenesis: HJC0123, a Potential Therapeutic Agent for Liver Fibrosis. RSC Adv. 2016;6 (102) :100652-100663.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-6; STAT3
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