CBR-096-4
CBR-096-4 is a derivative of Itraconazole. CBR-096-4 is an orally active antifibrotic agent with no CYP3A4 inhibitory activity. CBR-096-4 inhibits the formation of matrix-secreting activated myofibroblasts (MFBs) from multiple tissue types. CBR-096-4 inhibits Hedgehog reporter activity (GLI-LUC), VEGF-dependent growth, and αSMA-LUC reporter activity. CBR-096-4 can be used for research of fibrosis[1].
Product Specifications
CAS Number
1776931-05-5
UNSPSC
12352005
Target
Hedgehog
Related Pathways
Stem Cell/Wnt
Field of Research
Inflammation/Immunology
Smiles
O=C1N(C(C)CC)N=CN1C2=CC=C(N3CCN(C4=CC=C(OC[C@@H]5O[C@](C6=CC=CC=C6)(CN7N=CC=N7)OC5)C=C4)CC3)C=C2
Molecular Formula
C35H40N8O4
Molecular Weight
636.74
References & Citations
[1]Bollong MJ, et al. Small molecule-mediated inhibition of myofibroblast transdifferentiation for the treatment of fibrosis. Proc Natl Acad Sci U S A. 2017 May 2;114 (18) :4679-4684.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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