INU-101

INU-101 is a potent, selective and orally active 11β-hydroxysteroid dehydrogenase (11β-HSD) type 1 inhibitor. INU-101 has highly potent inhibitory activity in mouse, monkey and human 11β-HSD1, derived from liver microsomes. INU-101 can enhance insulin sensitivity and lower the fasting blood glucose level. INU-101 can be used for the research of metabolic disease, such as diabetes[1].

Product Specifications

CAS Number

[1513828-41-5]

UNSPSC

12352005

Target

11β-HSD

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Smiles

NC([C@]12C[C@@H](C3)C(NC(C(C)(C)NS(=O)(C4=C(C=CC=C4)F)=O)=O)[C@@H](C[C@@H]3C2)C1)=O

Molecular Formula

C21H28FN3O4S

Molecular Weight

437.53

References & Citations

[1]Hong SP, et al. A novel highly potent and selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, INU-101. Eur J Pharmacol. 2018 Sep 15;835:169-178.