BLX-2477

BLX-2477 is a potent and selective 15-lipoxygenase-1 (15-LOX-1) inhibitor with an IC50 value of 99 nM. BLX-2477 can inhibit the generation of inflammatory lipid mediators such as 15-hydroxy-eicosatetraenoic acid (15-HETE) . BLX-2477 can be used for the research of inflammation and immunology[1].

Product Specifications

CAS Number

[1080008-87-2]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Lipoxygenase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Smiles

O=C(C1=NNN=C1)NC2=CC=C(Cl)C=C2Cl

Molecular Formula

C9H6Cl2N4O

Molecular Weight

257.08

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Pelcman B, et al. 3-Substituted pyrazoles and 4-substituted triazoles as inhibitors of human 15-lipoxygenase-1. Bioorg Med Chem Lett. 2015 Aug 1;25 (15) :3024-9.