Medermycin

Lactoquinomycin A is a quinone antibiotic. Lactoquinomycin A has the activity of anti-Gram-positive bacteria and some Gram-negative bacteria, but the effect of anti-Gram-negative bacteria is weak and has no effect on fungi. Lactoquinomycin A inhibits a variety of cell lines including lymphoma L5178Y progenitor, Adriamycin resistant, Bleomycin-resistant, human leukemia K562, mouse leukemia L-1210 and mouse leukemia P 388 with ID50 (μg/mL) of 0.02, 0.006, 0.008, 0.033, 0.013 and 0.03, respectively[1].

Product Specifications

CAS Number

[60227-09-0]

Product Name Alternative

Lactoquinomycin A; LQM-A

UNSPSC

12352005

Target

Antibiotic; Bacterial

Related Pathways

Anti-infection

Field of Research

Cancer; Infection

Smiles

O=C1C2=C(C(C3=C(O)C([C@H]4C[C@H]([C@@H]([C@H](O4)C)O)N(C)C)=CC=C31)=O)[C@@H](C)O[C@@](C5)([H])[C@]2([H])OC5=O

Molecular Formula

C24H27NO8

Molecular Weight

457.47

References & Citations

[1]Beomkoo Chung, et al. Antibacterial Activity and Mode of Action of Lactoquinomycin A from Streptomyces bacillaris. Mar Drugs. 2020 Dec 24;19 (1) :7.