5,6,7,8-Tetrahydro-8-deazahomofolic acid
5,6,7,8-Tetrahydro-8-deazahomofolic acid is a potential thymidylate synthase (TS) inhibitor with inhibitory activity against other folate-related enzymes. 5,6,7,8-Tetrahydro-8-deazahomofolic acid showed mild growth inhibition against enterococci, lactic acid bacteria, and L1210 cells in culture. 5,6,7,8-Tetrahydro-8-deazahomofolic acid also showed weak inhibition against thymidylate synthase, dihydrofolate reductase, glycyl-ribonucleoside aminotransferase, and aminoimidazole-carboxyacyl-ribonucleoside aminotransferase. 5,6,7,8-Tetrahydro-8-deazahomofolic acid showed low substrate activity for thymidylate synthase[1].
Product Specifications
CAS Number
111113-75-8
UNSPSC
12352005
Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
O=C1C2=C(NC(N)=N1)CC[C@@H](N2)CCNC3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(O)=O)=O
Molecular Formula
C21H26N6O6
Molecular Weight
458.47
References & Citations
[1]Synthesis and biological evaluation of 8-deazahomofolic acid and its tetrahydro derivative
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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