GSI-136
GSI-136 is an inhibitor of γ-secretase with an IC50 of 3 nM. GSI-136 can lead to a dose-dependent reduction of Aβ40 levels in diethylamine-extracted brain homogenates of C57BL/6 mice. GSI-136 can be studied in medicinal chemistry and Alzheimer's disease research[1].
Product Specifications
CAS Number
443989-01-3
UNSPSC
12352005
Target
γ-secretase
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
O=S(C1=CC=C(S1)Cl)(N[C@H](CO)C(CC)CC)=O
Molecular Formula
C11H18ClNO3S2
Molecular Weight
311.85
References & Citations
[1]Chinthakindi, P. K., et al., (2017) . Sulfonimidamides in Medicinal and Agricultural Chemistry. Angewandte Chemie (International ed. in English), 56 (15), 4100-4109. |[2]Sehgelmeble, F., et al., (2012) . Sulfonimidamides as sulfonamides bioisosteres: rational evaluation through synthetic, in vitro, and in vivo studies with γ-secretase inhibitors. ChemMedChem, 7 (3), 396-399.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
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