GSI-136

GSI-136 is an inhibitor of γ-secretase with an IC50 of 3 nM. GSI-136 can lead to a dose-dependent reduction of Aβ40 levels in diethylamine-extracted brain homogenates of C57BL/6 mice. GSI-136 can be studied in medicinal chemistry and Alzheimer's disease research[1].

Product Specifications

CAS Number

[443989-01-3]

UNSPSC

12352005

Target

γ-secretase

Related Pathways

Neuronal Signaling; Stem Cell/Wnt

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

O=S(C1=CC=C(S1)Cl)(N[C@H](CO)C(CC)CC)=O

Molecular Formula

C11H18ClNO3S2

Molecular Weight

311.85

References & Citations

[1]Chinthakindi, P. K., et al., (2017) . Sulfonimidamides in Medicinal and Agricultural Chemistry. Angewandte Chemie (International ed. in English), 56 (15), 4100-4109. |[2]Sehgelmeble, F., et al., (2012) . Sulfonimidamides as sulfonamides bioisosteres: rational evaluation through synthetic, in vitro, and in vivo studies with γ-secretase inhibitors. ChemMedChem, 7 (3), 396-399.