KS 501

KS 501 is a potent and selective calmodulin inhibitor. KS 501 inhibits the activation of calmodulin kinase I and II, but has less effect against cyclic adenosine 3’,5’-monophosphate (cyclic AMP) -sensitive kinase. KS 501 inhibits the enzyme through interfering with calmodulin activation rather than through a direct effect on the enzyme. KS 501 can be used for the study of leukemia[1].

Product Specifications

CAS Number

[120634-86-8]

UNSPSC

12352005

Target

Calmodulin

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Cancer

Smiles

O[C@@H]1[C@H](O)[C@@H](OC2=C(C(CCCCCCC)=CC(O)=C2)C(OC3=CC(CCCCCCC)=CC(O)=C3)=O)O[C@@]1([C@H](O)CO)[H]

Molecular Formula

C33H48O10

Molecular Weight

604.73

References & Citations

[1]Hait WN, et al. Effects of KS-501, KS-502 and their enantiomers on calmodulin-sensitive enzyme activity and cellular proliferation. Biochem Pharmacol. 1995 Jun 29;50 (1) :69-74.