NRX-204647

NRX-204647 is a potent activator of retinoic acid nuclear (RAR) with higher specificity than that to RAR and RAR. NRX-204647 can inhibit bone formation. NRX-204647 significantly reduces bone volume/tissue volume (BV/TV) . NRX-204647 can be studied in anti-cancer research[1][2].

Product Specifications

CAS Number

[1351452-80-6]

UNSPSC

12352005

Target

RAR/RXR

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(C1=CC=C(C=C1)/C=C/C(C2=CC=C3C(C)(CCC(C)(C3=C2)C)C)=N/O)O

Molecular Formula

C24H27NO3

Molecular Weight

377.48

References & Citations

[1]Uchibe, K., et al., (2017) . Genetic and pharmacological inhibition of retinoic acid receptor γ function promotes endochondral bone formation. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 35 (5), 1096-1105.|[2]Garcia, S. A., et al., (2020) . Understanding the Action of RARγ Agonists on Human Osteochondroma Explants. International journal of molecular sciences, 21 (8), 2686.