NRX-204647
NRX-204647 is a potent activator of retinoic acid nuclear (RAR) with higher specificity than that to RAR and RAR. NRX-204647 can inhibit bone formation. NRX-204647 significantly reduces bone volume/tissue volume (BV/TV) . NRX-204647 can be studied in anti-cancer research[1][2].
Product Specifications
CAS Number
1351452-80-6
UNSPSC
12352005
Target
RAR/RXR
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(C1=CC=C(C=C1)/C=C/C(C2=CC=C3C(C)(CCC(C)(C3=C2)C)C)=N/O)O
Molecular Formula
C24H27NO3
Molecular Weight
377.48
References & Citations
[1]Uchibe, K., et al., (2017) . Genetic and pharmacological inhibition of retinoic acid receptor γ function promotes endochondral bone formation. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 35 (5), 1096-1105.|[2]Garcia, S. A., et al., (2020) . Understanding the Action of RARγ Agonists on Human Osteochondroma Explants. International journal of molecular sciences, 21 (8), 2686.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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