L-735821
L-735821 is a Potassium channel blocker and an antagonist of IKs. L-735821 inhibits the KCNQ1 channel activity with an EC50 of 0.08 μM. L-735821 can increase IKs and IKr current-voltage relations in rabbit ventricular myocytes. L-735821 fully abolishes IKs in isolated human ventricular myocytes at 100 nmol/L. L-735821 can easily enter single myocytes[1][2][3][4].
Product Specifications
CAS Number
170228-29-2
UNSPSC
12352005
Target
Potassium Channel
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
O=C(/C=C/C1=CC=C(C=C1Cl)Cl)N[C@H]2C(N(C3=CC=CC=C3C(C4=CC=CC=C4)=N2)C)=O
Molecular Formula
C25H19Cl2N3O2
Molecular Weight
464.34
References & Citations
[1]Lengyel, C., et al., (2001) . Pharmacological block of the slow component of the outward delayed rectifier current (I (Ks) ) fails to lengthen rabbit ventricular muscle QT (c) and action potential duration. British journal of pharmacology, 132 (1), 101-110. |[2]ost, N., et al., (2005) . Restricting excessive cardiac action potential and QT prolongation: a vital role for IKs in human ventricular muscle. Circulation, 112 (10), 1392-1399.|[3]Manikkam, M., et al., (2002) . Potassium channel antagonists influence porcine granulosa cell proliferation, differentiation, and apoptosis. Biology of reproduction, 67 (1), 88-98.|[4]Tinel, N., et al., (1998) . The KCNQ2 potassium channel: splice variants, functional and developmental expression. Brain localization and comparison with KCNQ3. FEBS letters, 438 (3), 171-176.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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