GW 275175X

GW 275175X is an inhibitor of the terminase complex involved in cleavage and packaging of the unit length DNA into the capsids. GW 275175X exhibits long plasma half-life. GW 275175X is a BDCRB derivative. GW 275175X exhibits anti-HCMV activity through inhibiting maturation of viral DNA[1][2][3].

Product Specifications

CAS Number

[217950-62-4]

UNSPSC

12352005

Target

CMV

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Smiles

O[C@H]1[C@H](N2C3=CC(Cl)=C(Cl)C=C3N=C2Br)OC[C@@H](O)[C@H]1O

Molecular Formula

C12H11BrCl2N2O4

Molecular Weight

398.04

References & Citations

[1]Emery, V. C., & Hassan-Walker, A. F. (2002) . Focus on new drugs in development against human cytomegalovirus. Drugs, 62 (13), 1853-1858.|[2]Williams, S. L., et al., (2003) . In vitro activities of benzimidazole D- and L-ribonucleosides against herpesviruses. Antimicrobial agents and chemotherapy, 47 (7), 2186-2192.|[3]McGregor, A., & Choi, K. Y. (2011) . Cytomegalovirus antivirals and development of improved animal models. Expert opinion on drug metabolism & toxicology, 7 (10), 1245-1265.