BMS-210285

BMS-210285 is a highly selective agonist for the 3 receptor. BMS-210285 has a Ki of 9 nM at the human 3-adrenoceptor. BMS-210285 possesses a 3 intrinsic activity of 83% relative to isoproterenol. BMS-210285 can be studied for obesity and type 2 diabetes research[1][2].

Product Specifications

CAS Number

[344607-69-8]

UNSPSC

12352005

Target

Adrenergic Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Smiles

CS(=O)(NC1=CC([C@@H](O)CN[C@@H](C2=CC=C(OC(F)F)C=C2)CC3=CC=CC(Cl)=C3)=CC=C1O)=O

Molecular Formula

C24H25ClF2N2O5S

Molecular Weight

526.98

References & Citations

[1]Hu, B., & Jennings, L. L. (2003) . Orally bioavailable beta 3-adrenergic receptor agonists as potential therapeutic agents for obesity and type-II diabetes. Progress in medicinal chemistry, 41, 167-194.|[2]Kordik, C. P., & Reitz, A. B. (1999) . Pharmacological treatment of obesity: therapeutic strategies. Journal of medicinal chemistry, 42 (2), 181-201.