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NY-0173

NY-0173 is an antagonist of Exchange proteins directly activated by cAMP (EPAC), with IC50s of 3.5 μM (EPAC2) and 4.0 μM (EPAC1) respectively. NY-0173 can be used to elucidate the biological functions of EPAC and developing potential novel therapeutics against human diseases[1].

Product Specifications

CAS Number

1801911-86-3

UNSPSC

12352005

Target

Ras

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Field of Research

Others

Smiles

ClC1=C(Cl)C(Cl)=CC(N/N=C(C#N)/C(C2=NOC(C3CCCCC3)=C2)=O)=C1

Molecular Formula

C18H15Cl3N4O2

Molecular Weight

425.70

References & Citations

[1]Ye N, et al. Structure-Activity Relationship Studies of Substituted 2- (Isoxazol-3-yl) -2-oxo-N'-phenyl-acetohydrazonoyl Cyanide Analogues: Identification of Potent Exchange Proteins Directly Activated by cAMP (EPAC) Antagonists. J Med Chem. 2015 Aug 13;58 (15) :6033-47.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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