YM-359445 (dihydroxybutanedioate)

YM-359445 dihydroxybutanedioate is an orally active VEGFR2 tyrosine kinase inhibitor, with an IC50 of 8.5 nM. YM-359445 dihydroxybutanedioate shows a complete inhibition of vascular permeability induced by VEGF. YM-359445 dihydroxybutanedioate shows antitumor activity against both lung cancer and Paclitaxel (HY-B0015) -resistant colon cancer[1].

Product Specifications

CAS Number

[1020067-28-0]

UNSPSC

12352005

Target

VEGFR

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

OC([C@H](O)[C@@H](O)C(O)=O)=O.O=C1/C(C2=CC=C(/C=N/OCC3=CSC=N3)C=C2N1)=C4NC5=CC=C(CN6CCN(C)CC6)C=C5C=C\4

Molecular Formula

C32H34N6O8S

Molecular Weight

662.71

References & Citations

[1]Amino N, et al. YM-359445, an orally bioavailable vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor, has highly potent antitumor activity against established tumors. Clin Cancer Res. 2006 Mar 1;12 (5) :1630-8.