RO 5073012
RO 5073012 is a selective, orally active and brain-penetrant TAAR1 agonist. RO 5073012 shows a Ki of 6 nM for hTAAR1 and EC50 values of 23 and 25 nM for mTAAR1 and rTAAR1. RO 5073012 can be used for the research of neurological disease, such as schizophrenia[1].
Product Specifications
CAS Number
1020814-70-3
UNSPSC
12352005
Target
Trace Amine-associated Receptor (TAAR)
Related Pathways
GPCR/G Protein
Field of Research
Neurological Disease
Smiles
CC(N(C1=CC=C(Cl)C=C1)CC2=CN=CN2)C
Molecular Formula
C13H16ClN3
Molecular Weight
249.74
References & Citations
[1]Galley G, et al. Optimisation of imidazole compounds as selective TAAR1 agonists: discovery of RO5073012. Bioorg Med Chem Lett. 2012 Aug 15;22 (16) :5244-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TAAR1
Frequently Asked Questions
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