D156844 (hydrochloride)

D156844 (Compound 11a) hydrochloride is a SMN2 promoter activator with an EC50 of 4 nM. D156844 hydrochloride increases the mRNA expression of the mouse SMN in NSC-34 cells and human SMN2 promoter in severe type I spinal muscular atrophy (SMA) fibroblasts as well as full-length human SMN protein. D156844 hydrochloride overcomes DHFR inhibition. D156844 hydrochloride can be used for SMA research[1].

Product Specifications

UNSPSC

12352100

Target

Dihydrofolate reductase (DHFR) ; DNA/RNA Synthesis

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Neurological Disease

Smiles

NC1=NC(N)=C2C(OCC3CCN(CC4=CC=CC=C4F)CC3)=CC=CC2=N1.[H]Cl.[H]Cl

Molecular Formula

C21H26Cl2FN5O

Molecular Weight

454.37

References & Citations

[1]Thurmond J, et al. Synthesis and biological evaluation of novel 2,4-diaminoquinazoline derivatives as SMN2 promoter activators for the potential treatment of spinal muscular atrophy. J Med Chem. 2008 Feb 14;51 (3) :449-69.