D156844 (hydrochloride)
D156844 (Compound 11a) hydrochloride is a SMN2 promoter activator with an EC50 of 4 nM. D156844 hydrochloride increases the mRNA expression of the mouse SMN in NSC-34 cells and human SMN2 promoter in severe type I spinal muscular atrophy (SMA) fibroblasts as well as full-length human SMN protein. D156844 hydrochloride overcomes DHFR inhibition. D156844 hydrochloride can be used for SMA research[1].
Product Specifications
UNSPSC
12352100
Target
Dihydrofolate reductase (DHFR) ; DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Neurological Disease
Smiles
NC1=NC(N)=C2C(OCC3CCN(CC4=CC=CC=C4F)CC3)=CC=CC2=N1.[H]Cl.[H]Cl
Molecular Formula
C21H26Cl2FN5O
Molecular Weight
454.37
References & Citations
[1]Thurmond J, et al. Synthesis and biological evaluation of novel 2,4-diaminoquinazoline derivatives as SMN2 promoter activators for the potential treatment of spinal muscular atrophy. J Med Chem. 2008 Feb 14;51 (3) :449-69.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![PerCP Anti-Human CD8a Antibody[OKT-8]](https://cdn.genprice.uk/products/763/68dd14b4061270361e7d4639/imageurl/e-ab-f1110f.webp)