D156844
D156844 (Compound 11a) is a SMN2 promoter activator with an EC50 of 4 nM. D156844 increases the mRNA expression of the mouse SMN in NSC-34 cells and human SMN2 promoter in severe type I spinal muscular atrophy (SMA) fibroblasts as well as full-length human SMN protein. D156844 overcomes DHFR inhibition. D156844 can be used for SMA research[1].
Product Specifications
CAS Number
[1005501-84-7]
UNSPSC
12352005
Target
Dihydrofolate reductase (DHFR) ; DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Field of Research
Neurological Disease
Smiles
NC1=NC(N)=C2C(OCC3CCN(CC4=CC=CC=C4F)CC3)=CC=CC2=N1
Molecular Formula
C21H24FN5O
Molecular Weight
381.45
References & Citations
[1]Thurmond J, et al. Synthesis and biological evaluation of novel 2,4-diaminoquinazoline derivatives as SMN2 promoter activators for the potential treatment of spinal muscular atrophy. J Med Chem. 2008 Feb 14;51 (3) :449-69.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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