BMY 7378 (free base)

BMY 7378 (free base) is a selective antagonist of α1D-adrenoceptor (α1D-AR) . BMY 7378 (free base) binds to membranes expressing the cloned rat α1D-AR with a >100-fold higher affinity (Ki=2 nM) than binding to either the cloned rat α1A-AR (Ki=800 nM) or the hamster α1B-AR (Ki=600 nM) . BMY 7378 (free base) is a 5-HT1A receptor partial agonist[1][2].

Product Specifications

CAS Number

[21102-94-3]

UNSPSC

12352005

Target

5-HT Receptor; Adrenergic Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Smiles

O=C(N(CCN1CCN(C2=CC=CC=C2OC)CC1)C(C3)=O)CC43CCCC4

Molecular Formula

C22H31N3O3

Molecular Weight

385.50

References & Citations

[1]Piascik MT, et al. The specific contribution of the novel alpha-1D adrenoceptor to the contraction of vascular smooth muscle. J Pharmacol Exp Ther. 1995;275 (3) :1583-1589.|[2]Goetz AS, et al. BMY 7378 is a selective antagonist of the D subtype of alpha 1-adrenoceptors. Eur J Pharmacol. 1995;272 (2-3) :R5-R6.