A-357300
A-357300 is a reversible and selective MetAP2 inhibitor with IC50s of 0.12 and 57 μM against MetAP2 and MetAP1. A-357300 induces cytostasis by cell cycle arrest at the G1 phase selectively in endothelial cells and in a subset of tumor cells. A-357300 inhibits angiogenesis both in vitro and in vivo and shows potent antitumor efficacy in carcinoma, sarcoma, and neuroblastoma murine models. A-357300 can be used for the studies of neuroblastoma, fibrosarcoma and breast cancer[1].
Product Specifications
CAS Number
369358-07-6
UNSPSC
12352005
Target
MetAP
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
CC(C)SCC[C@@H](N)[C@H](O)C(NNC(C1=CC(Cl)=CC=C1)=O)=O
Molecular Formula
C15H22ClN3O3S
Molecular Weight
359.87
References & Citations
[1]Wang J, ET AL. Tumor suppression by a rationally designed reversible inhibitor of methionine aminopeptidase-2. Cancer Res. 2003 Nov 15;63 (22) :7861-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MetAP1; MetAP2
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