P38α inhibitor 7
P38α inhibitor 7 (compound 1) is an effective p38α inhibitor with oral efficacy and generally favorable pharmacokinetic properties[1].
Product Specifications
CAS Number
[668981-02-0]
UNSPSC
12352005
Target
P38 MAPK
Related Pathways
MAPK/ERK Pathway
Field of Research
Inflammation/Immunology
Smiles
FC1=CC(C2=C(C3=CN4C(C(C)C)=NN=C4C=C3)OC=N2)=C(F)C=C1
Molecular Formula
C18H14F2N4O
Molecular Weight
340.33
References & Citations
[1]Amit S. Kalgutkar, et al. Preclinical Pharmacokinetics and Metabolism of 6- (4- (2,5- Difluorophenyl) oxazol-5-yl) -3-isopropyl-[1,2,4]-triazolo[4,3-a] pyridine, a Novel and Selective p38a Inhibitor: Identification of an Active Metabolite in Preclinical Species and Human Liver Microsomes. Biopharm. Drug Dispos. 27: 371–386 (2006) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P38α
Curated Selection
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