Amorphigenin

Amorphigenin is a trothotenone compound. Amorphigenin inhibits osteoclast differentiation by suppressing the expression of c-Fos and NFATc1 in activated T cells. Amorphigenin degrades melanosome proteins by activating the AMPK-dependent autophagy pathway, but not in dependence of the mTOR pathway. Amorphigenin significantly protects bone mass and reduces bone erosion in a mouse model of inflammatory bone loss. Amorphigenin can be used to study inflammatory bone diseases, postmenopausal osteoporosis, and skin pigmentation disorders[1][2].

Product Specifications

CAS Number

[4208-09-7]

UNSPSC

12352005

Target

AMPK; AP-1; Autophagy; Nuclear Factor of activated T Cells (NFAT)

Related Pathways

Autophagy; Epigenetics; Immunology/Inflammation; PI3K/Akt/mTOR

Field of Research

Endocrinology; Metabolic Disease; Inflammation/Immunology

Smiles

O=C1[C@@]2([C@]([H])(OC3=C1C=CC4=C3C[C@@H](O4)C(CO)=C)COC5=C2C=C(C(OC)=C5)OC)[H]

Molecular Formula

C23H22O7

Molecular Weight

410.42

References & Citations

[1]Lee KW, et al. Root Extract Induces Autophagy-Mediated Melanosome Degradation in mTOR-Independent- and AMPK-Dependent Manner. Curr Issues Mol Biol. 2022 Jun 29;44 (7) :2856-2867.|[2]Kim BG, et al. Amorphigenin inhibits Osteoclast differentiation by suppressing c-Fos and nuclear factor of activated T cells. Anat Cell Biol. 2010 Dec;43 (4) :310-6.