Tetrahydromagnolol

Tetrahydromagnolol (Magnolignan), the main metabolite of Magnolol, is a potent and selective cannabinoidCB2 receptor agonist (EC50 =170 nM) and GPR55 antagonist. The Ki of Tetrahydromagnolol for CB2 is 416 nM, 20-fold higher than for the CB1 receptor. Magnolol shows antifungal, anti-inflammatory and analgesic effects[1][2][3][4].

Product Specifications

CAS Number

[20601-85-8]

Product Name Alternative

Magnolignan

UNSPSC

12352005

Target

Cannabinoid Receptor; Drug Metabolite; GPR55

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology; Neurological Disease

Purity

99.89

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC=C(CCC)C=C1C2=CC(CCC)=CC=C2O

Molecular Formula

C18H22O2

Molecular Weight

270.37

References & Citations

[1]Alexander Fuchs, et al. The natural product magnolol as a lead structure for the development of potent cannabinoid receptor agonists. PLoS One. 2013 Oct 30;8 (10) :e77739.|[2]Rempel V, et al. Magnolia Extract, Magnolol, and Metabolites: Activation of Cannabinoid CB2 Receptors and Blockade of the Related GPR55. ACS Med Chem Lett. 2012 Nov 14;4 (1) :41-5.|[3]Wang JP, et al. Anti-inflammatory and analgesic effects of magnolol. Naunyn Schmiedebergs Arch Pharmacol. 1992 Dec;346 (6) :707-12.|[4]Bang KH, et al. Antifungal activity of magnolol and honokiol. Arch Pharm Res. 2000 Feb;23 (1) :46-9.